Can also affect GI tract, bone marrow & other extra-nodal tissues
Intravascular lymphoma (rare) can have systemic sx, but no findings (dx by random skin bx)
Can directly invade connective tissue of PNS or Cranial Nerves, causing neurolymphomatosis; most common symptom is pain; also numbness and weakness; overall uncommon (5% of lymphomas) but occurs mostly in DLBC
Overall, tends to be aggressive, w/rapid development of symptoms and findings