Stomach, salivary glads, lacrimal glads, small intestine; less commonly lymph nodes, spleen
Etiology
5-10% of NHL
Average age 60s
Most common is MALT (Mucosa Associated Lymphoid Tissue) lymphoma
MALT is extra-nodal (i.e. occurs in mucosal tissue)
MALT most commonly affects stomach; also lacrimal glands, salivary glands, thyroid, small intestine, lung, other
Other marginal zone lymphomas are less common, arising in lymph nodes or spleen
Risk Factors
H pylori for gastric MALT
Sjogrens for salivary and lacrimal MALT
Symptoms
Slow growing
Symptoms related to location: Stomach--> vague dyspepsia, vague epigastric pain, slow blood loss, wt loss; thyroid, salivary, lacrimal--> painless masses in those areas
Other sx can relate to local disruption in organ function
Starts local and spreads late
Physical Exam Findings
Slow growing, painless mass in area affected--> salivary, thyroid, lacrimal, etc