Waldenstroms Macroglobulinemia

Your Path

  • Waldenstroms Macroglobulinemia

Etiology

  • 1-2% of NHL
  • Associated with inappropriate production IgM

Risk Factors

  • Hx
  • MGUS
  • Average age 63

Symptoms

  • Fever
  • Chills
  • Sweat
  • Weight loss
  • Fatigue
  • Raynauds
  • Digital ulcers
  • Hyerviscocity→ blurred vision (venous congestion retina), ha, dizziness
  • Mucosal bleeding
  • Abd discomfort from organomegaly
  • Peripheral neuropathy

Physical Exam Findings

  • Hepatomegaly
  • Splenomegaly
  • Adenopathy
  • Raynauds
  • Digital ulcers
  • Urticaria from type 1 cryglobulins
  • Mucosal bleeding
  • Decreased visual acuity; dilated, sausage shaped retinal veins