- Associated with inappropriate production IgM
- Fever
- Chills
- Sweat
- Weight loss
- Fatigue
- Raynauds
- Digital ulcers
- Hyerviscocity→ blurred vision (venous congestion retina), ha, dizziness
- Mucosal bleeding
- Abd discomfort from organomegaly
- Peripheral neuropathy
- Hepatomegaly
- Splenomegaly
- Adenopathy
- Urticaria from type 1 cryglobulins
- Mucosal bleeding
- Decreased visual acuity; dilated, sausage shaped retinal veins