Creutzfeldt-Jacob Disease (CJD)

Etiology

  • Transmissible Spongiform Encephalopathy (TSE)
  • Infectious variant (uncommon) can be spread by contact w/infected brain matter (via prions)
  • Most common is sporadic form, which is non-infectious
  • Also a hereditary form

Risk Factors

  • Avg age onset in 60s
  • Though can affect old & young (<50)

Symptoms

  • Rapidly progressive decline in memory, cognition, thinking
  • Onset to death w/in 1y
  • Coordination problems and myoclonus may come first

Physical Exam Findings

  • Coordination problems and myoclonus

Links