Cushing's Disease (Glucocorticoid Excess)

Etiology

  • Excess ACTH
  • Adrenal tumor
  • Chronic cortico-steroid use

Symptoms

  • Htn
  • Muscle weakness
  • Easy bruising
  • Central wt gain→ neck/face/thorax/abd
  • Glucose intol/dm

Physical Exam Findings

  • Echymoses
  • Buffalo hump
  • Moon face
  • Purple/red striae
  • Hyperpigment in mouth/sun exposed areas if acth depen

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