Qualitative Platelet Disorder

Etiology

  • Meds causing platelet dysfxn→ aspirin, clopidogrel
  • Metabolic d/o affecting platelet function→ renal failure, multiple myeloma
  • Essential thrombocytosis (ET)→ some patients have increased risk bleeding, others clotting
  • Acquired Von Willebrand dz→ avg age 60s, assoc w/myeloproliferative disorders, multiple myeloma, mgus, hypothyroidism, c/v dz w/high shear forces→ abnl valves, VSDs, LVADs; meds→ cipro, valproate; Sx develop later in life

Symptoms

  • Spontaneous mucocutanous bleeding → gums, nosebleeds, GI tract
  • Excessive bleeding w/menstruation, following routine dentistry, after minor trauma

Physical Exam Findings

  • PE: petechiae
  • Spontaneous ecchymoses
  • Mucosal hemorrhage

Links