- Meds causing platelet dysfxn→ aspirin, clopidogrel
- Metabolic d/o affecting platelet function→ renal failure, multiple myeloma
- Essential thrombocytosis (ET)→ some patients have increased risk bleeding, others clotting
- Acquired Von Willebrand dz→ avg age 60s, assoc w/myeloproliferative disorders, multiple myeloma, mgus, hypothyroidism, c/v dz w/high shear forces→ abnl valves, VSDs, LVADs; meds→ cipro, valproate; Sx develop later in life
- Spontaneous mucocutanous bleeding → gums, nosebleeds, GI tract
- Excessive bleeding w/menstruation, following routine dentistry, after minor trauma
- Spontaneous ecchymoses
- Mucosal hemorrhage