Impaired Coagulation Pathways

Etiology

  • Meds: e.g. warfarin use, heparin, DOACs
  • Processes that consume coag factors→ DIC
  • Processes that decrease production of coagulation factors→ advanced liver dz, vit K deficiency
  • Acquired inhibitors to coagulation factors→ inhibitor to factor 8 or other, though all uncommon; assoc w/leukemia, lymphoma, myeloma, rheum dz, post-partum state, meds

Symptoms

  • Hematomas
  • Spontaneous or minimally provoked hemarthroses
  • Delayed hemorrhage after trauma

Physical Exam Findings

  • Excessive bleeding after trauma
  • Unexplained hemarthroses