Acute tubular necrosis can result from: hypotension/hypoperfusion; Contrast nephropathy; myoglobin induced injury from rhabdomyolysis; other toxins
Often the result of multiple contributors
ATN is a common cause of AKI in hospitalized patients: related to co-morbidities, frequency of hypo perfusion syndromes, exposure to IV contrast agents
Risk Factors
Pre-existing chronic renal disease from DM, HTN, other
Symptoms
Fatigue
Edema/general volume overload
Diminished or absent urine output in acute phase
Symptoms related to the primary process (if there is one) causing hypo-perfusion