Myelodysplastic Syndrome (MDS)

Etiology

  • Clonal stem cell disorder leading to ineffective hematopoeisis and cytopenias
  • Marrow is hypercellular, but cells made are abnormal and die prior to leaving
  • Can be primary problem or secondary to chemotherapy/other disorders that affect BM function

Risk Factors

  • Average age 70s

Symptoms

  • Asx until anemia→ fatigue, sob, doe, weakness/falls, other
  • Progresses over years
  • Low plt or low/abnormal WBC can cause bleeding, infection
  • Risk of transformation to AML

Tests