Mutation in protein that's part of intercellular cytoskeleton - such that shear forces applied to skin break up cells
Affects deeper aspects epidermal layer
Risk Factors
Family history
Symptoms
Recurrent blister formation at areas of skin subjected to force--> e.g. feet
Can present at birth, with blisters around head, shoulders, elsewhere--> sites of friction during delivery
Significant variation in severity, based on precise mutation and degree of structural weakening of cytoskeleton; also varies with level of activity of individual