- Related to severe, systemic infection, often Neisseria Meningitidis (meningococcemia) or Pneumococcal sepsis that causes DIC
- Can be other micro as well
- Can occur in anyone
- Higher risk if immunocompromised, s/p splenectomy (pneumococcus, h flu), unvaccinated
- Spreading, purpuric skin lesions
- Other findings of severe illness including fever, confusion, N, V, other
- Evolves over hours, w/high mortality unless prompt intervention
- Fever, tachycardia, hypotension and other findings severe illness
- Purpuric (blue/gray/purple) lesions that develop quickly in multiple areas of the body, often hands, feet, and limbs
- Progress quickly to necrosis (black tissue)