- Environmentally triggered
- Transmural involvement--> strictures, fistulae
- Can affect anywhere in GI tract mouth-to-anus
- Smoking and appendectomy increase risk
- Northern Europeans and North Americans
- Peak onset 15-30
- Sub-acute
- Mucous
- Cramps
- Constipation
- Fever
- And pain
- Fatigue
- Wt loss
- Fistulas
- Peri-rectal dz
- Diarrhea→ though can be less prominent than w/UC
- Nocturnal diarrhea
- Sometimes bloody stools
- Feeling poorly overall
- Bowel obstruction
- Spectrum of sx and findings
- DVT: risk markedly increased w/IBD flair, immobility and/or hospitalization
- Sometimes abd mass
- Peri-rectal disease
- Erythema nodosum
- Pyoderma gangrenosa
- Peripheral arthritis
- Ankylosing spond/sacroiliitis
- Primary sclerosing cholangitis
- Eye sx→ episcleritis/scleritis/uveitis