- Anemia and fatigue can result from significant blood loss (chronic or acute) anywhere along the GI tract
- Upper: Peptic ulcer disease (NSAIDs or H Pylori), esophagitis, gastritis, varices, cancer (esophageal, gastric), other
- Lower: cancer (colorectal, small bowel), hemorrhoids, angiodysplasia, polyps, chronic inflammation (IBD), XRT-induced, infection (intestinal parasites), diverticula, chronic mesenteric ischemia, other
- Fatigue is often slowly progressive (if slow losses), with generalized tiredness, SOB, low energ.
- With acute losses, symptoms of hypovolemia/hypo-perfusion