- Includes methamphetamines, cocaine, heroin, other
- Focus of life and money soley on drug use - to extent that dont purchase food, eat or otherwise look after nutritional needs
- Laxative, sorbitol use or abuse--> chronic diarrhea, malabsorption
- Excessive caffeine intake--> diarrhea, appetite suppression
- Co-morbid conditions may also contribute (e.g. other substance abuse, HIV, TB, other infections)