- Sub-mucosal artery that develops for unclear reasons
- Found most commonly in stomach, but can occur in esophagus, duodenum and colon
- Acute, profound GI bleeding (typically upper)
- Hematemesis and melena
- As arterial, blood loss often quick and large
- Can start and stop spontaneously
- Can have unstable Vital Signs (tachycardia, hypotension)
- Visible blood in vomitus
- Melena, guiac +; rarely BRBPR (if very brisk UGIB)