Loss of bicarbonate is off-set by rise in chloride
This allows acidosis to occur, with AG remaining normal
Common causes of Non-AG metabolic acidosis include: resuscitation w/large volumes of Normal Saline (high chloride content), losses of bicarbonate in GI tract (secretory diarrhea), loss of bicarb in urinary tract (types 1 and 4 renal tubular acidosis)
Risk Factors
CKD
Medications
Can have concurrent AG and Non-AG acidosis
Symptoms
Symptoms are based on underlying cause
Diarrhea (bicarb loss); CKD related; Medications, other
Non-specific symptoms could include: weakness, shortness of breath (compensatory tachypnea), confusion, other
Tests
Chemistry (to assess AG); often ABG (to assess pH)