Metabolic Acidosis| Other Metabolic Causes + AG Acidosis

Etiology

  • Renal failure
  • Diabetic ketoacidosis (DKA)
  • Alcoholic ketoacidosis (AKA)

Risk Factors

  • For DKA: previously undiagnosed or poorly treated type 1 diabetes
  • For AKA: typically malnourished
  • For renal failure: typically chronic, advanced renal disease (diabetes and htn most common)

Symptoms

  • Typically based on underlying disease
  • DKA: usually ill, polyuria, polydypsia
  • Chronic alcohol abuse related: chronic intoxication, often doing poorly w/life in general, may have symptoms related to chronic liver disease, GI bleeding
  • Renal failure: fatigue, nausea, generalized weakness; may have confusion (if uremia), volume overload

Physical Exam Findings

  • Sometimes tachypnea (compensatory)
  • May appear acute or chronically ill
  • Vital sign abnormalities based on magnitude of underlying conditions
  • Other findings based on underlying problems that lead to the acidosis