- Some medications can induce antibodies to react against RBCs: include cephalosporins, penicillins, check-point inhibitors, others
- Some medications induce hemolysis in setting of G6PD deficiency, including: rasburicase, dapsone, others
 
   
           
        
        
        
          
          
            
  
      
    
    
      
        
            - G6PD deficiency - more common in people from (or with ancestral ties to) Mediterranean, Asia, Africa, Middle East
 
   
           
        
        
        
          
          
            
  
      
    
    
      
        
            - SOB, fatigue, palpitations
 
   
           
        
        
        
          
          
        
       
      
      
  
  
    
      - Abrupt decrease in RBCs that's otherwise unexplained
- Elevated bilirubin, reticulocyte count,  LDH
- Decrease in haptoglobin