Lupus (SLE)

Etiology

  • Idiopathic/autoimmune
  • Drug induced→ hydralazine, procainamide, INH, others

Risk Factors

  • Female > Male
  • Black>White
  • Age onset 15-50

Symptoms

  • Sub-acute onset
  • Photosensitive
  • Rash on face
  • Fever and feeling poorly in general
  • Discoid eruption on body
  • Multi-system involvement including: CNS: confusion, seizures; kidney involvement; muscle aches, pain; inflammation of 2 or more peripheral joints→ can be migratory
  • SOB w/pleural, parenchymal, or pulmonary vascular (pulmonary htn) disease
  • CP if pericarditis
  • Weakness, numbness, or neuropathic pain w/PNS involvement (rare)
  • High risk atherosclerosis (MI, stroke)

Physical Exam Findings

  • Pericardial rub
  • Adenopathy
  • Painless oral ulcers
  • Malar and nasal bridge erruption sparing naso-labial folds
  • Discoid erruption on body
  • Pleural rub or findings of effusion
  • Inflammatory arthritis
  • Scarring hair loss
  • Elevated JVP, edema, loud P2, other findings of plum htn
  • Diminished peripheral sensation, decreased reflexes, weakness w/PN involvement

Tests

Links