- Upper and lower respiratory tract
- Heart--> myocarditis (rare)
- Brain--> encephalitis (rare)
- Systemic--> sepsis (rare)
- Common cause upper and lower respiratory infection
- Seasonal in North America Oct to April
- Increase risk amongst old, young, pregnant
- Chronic lung disease
- Any chronic illness
- Abrupt onset of myalgias, arthralgias, fever, chills, cough, runny nose, sore throat