Neuroleptic Malignant Syndrome

Etiology

  • Exposure to haldol, chlorpromazine, other typical or atypical neruoleptics
  • More common w/high dose or soon after rx/dose change, but also idiosyncratic→ occurring after years of rx
  • Sx progress over several d

Symptoms

  • Fluctuating delirium→ aggitated or stupor/alert mutism to coma

Physical Exam Findings

  • Pale and sweaty
  • Autonomic instability w/HTN, tachycardia, tachypnea
  • Temp can be > 41.1c
  • Mental status on spectrum from agitated to coma
  • Generalized lead-pipe type muscular rigidity
  • Decreased reflexes