Serotonin Syndrome

Etiology

  • SSRIs
  • MAOIs
  • Anti-epileptics, others
  • Rapid onset sx ususally following rx initiation or dose change, though can occur if received rx w/in 5w
  • Sometimes med combinations precipitate syndrome
  • Intential overdose

Symptoms

  • Sweating
  • Shivering
  • Diarrhea
  • Aggiation/easily startled

Physical Exam Findings

  • Spectrum→ htn
  • Tachycardia
  • Tachypnea
  • Tremor
  • Clonus
  • Hyper-reflexia
  • Hyperthermia to > 41c
  • Flushed & sweaty skin
  • Confusion/aggitation to coma
  • Increased bowel sounds
  • Muscular hyperactivity/stiffness