- Uncommon autoimmune disorder assoc
- Middle Eastern, Mediterranean, or Asian background
- Symptoms are typically episodic, waxing & waning over weeks to months
- Painful ulcers in genital region and mouth
- Painful, red eye; often w/decreased acuity (uveitis, retinal vasculitis)
- DVT or arterial insufficiency (hypercoaguable)
- Development of skin nodules
- Abd pain, diarrhea, melena
- CNS involvement: cerebral sinus thrombosis, stroke, parenchymal inflammation, seizures, cognitive impairment
- Painful oral and genital ulcers
- Red eye, irregular pupil, hypopyon, decreased visual acuity
- Inflammatory arthritis in one or few joints
- Erythema nodosum
- Pathergy--> papule/pustule in response to minor trauma