- Lungs, GI/GU tracts, pericardium, bones, cns, lymph nodes, bone marrow and/or widely disseminated
- Chronic kidney, liver, lung dz
- Immunocompromised for other reason→ steroid
- TNF inhibitors, other
- Though can occur in anyone, reactivating sometimes years after initial exposure
- Extra-pulm TB increases in HIV+ w/CD4 < 350
- Sub-acute
- Cough
- Hemoptysis
- Weight loss
- Sweats
- Fatigue
- Focal to site of main infection
- Can be chronically ill appearing
- Lung findings of crackles, diminished breath sounds
- Adenopathy (called scrofula if in head and neck region)
- Bone pain or sinus track if boney involvement (called Pott's disease if affects spine)
- Abnormalities over any other affected area