Hemophagocytic Lymphohistiocytosis (HLH)

Etiology

  • Uncontrolled activation of T Cells, w/inappropriate release of cytokines and macrophage activation
  • Rx directed at underlying cause

Risk Factors

  • Triggered by lymphoma, leukemia, autoimmunes dz, infxns→ ebv, enterovirus, gastroenteritis, other
  • Also a rare familial form

Symptoms

  • Fever that's unexplained
  • Other symptoms related to the inciting process (e.g. infection, cancer, auto-immune d/o, etc.)

Physical Exam Findings

  • F
  • Splenomegaly

Tests