- Nasal mucosa/upper airways
- Lung parenchyma (focal infiltrates, ILD)
- Peripheral nerves
- Fatigue
- Arthralgias
- Myalgias
- Sweats
- Wt loss
- Skin ulcers
- Recurrent/progressive cough, f, c, wheezing, hemoptysis
- Less often nasal sx c/w GPA
- Lab evidence glomerulonepthritis
- Often delays in dx as rx for more common infxn/inflam processes
- Peripheral neuropathy w/weakness, numbness
- Palpable purpura
- Skin ulcer/necrosis
- Peripheral neuropathy related: decreased distal sensation, weakness, diminished reflexes
- Lung findings consistent with focal infiltrate or ILD
- W/Renal involvement: UA + RBCs, protein; Urine microscopy w/rbc casts, dysmorphic RBCs
- Serum: decrease in GFR; often + p-anca