Biochemical predispositions, consider in particular when unexplained DVT: protein S or C defiicency, Anti-thrombin 3 defic, Prothrombin mutation, factor 5 leiden resistance, anti-phospholipid AB (arterial and venous)
Acquired predispositions, often linked to clots in unusual places: nephrotic syndorme (renal vein), p vera (hepatic vein), HIT, ET (arterial and venous), PNH, hyperhomocystinemia
Mechanical predispositions that compress veins→ stasis→ clot
Can have contribution from more than one RF
Upper extremity DVT in particular associated w/central venous catheters and/or cancer
Symptoms
Acute
Cough
SOB
Pleuritic cp
Hemoptysis
Physical Exam Findings
Tachycardia
Tachypnea
Often clear lungs
Less commonly wheezing or findings of effusion
Unexplained unilateral leg (or arm if UE DVT) swelling