- Brain→ meningitis & encephalitis
- Oral mucosa and skin→ hand/foot/mouth dz
- Heart→ myocarditis and pericarditis
- Conjunctiva→ conjunctivitits
- Upper resp tract
- Passed fecal-oral
- Ingesting infected water
- Most have mild illness
- W/more severe dz→ fever, ha, cough, runny nose, muscle aches, confusion