- Affecting exocrine glands
- Age typically >50
- Secondary Sjogrens: assoc w/RA, SLE, Scleroderma, other
- Dry eyes/gritty sensation
- Dry mouth which can affect speaking/swallowing
- Intermittent parotid region pain and swelling
- Markedly increased risk lymphoma
- SOB and DOE w/diffuse parenchymal lung disease (DPLD)
- Sometimes multiple systems→ painful peripheral neuropathy, myalgias, arthralgias, arthritis, raynauds, cutaneous vasculitis, other
- Dry mucous membranes
- Enlarged parotid & sub-mandibular glands
- Sometimes arthritis
- Sometimes peripheral neuropathy
- Sometimes adenopathy
- Dry crackles w/DPLD
- + anti-Ro/SSA, anti-La/SSB Antibodies in 2/3 of patients
- + RF in 1/2 of patients
- Definitive dx typically by parotid bx