- Lower 1/3 of esophagus
- Mechanically obstructs lumen
- Can also cause pseudoachalsia, where tumor at gastro-esophageal junction infiltrates myenteric plexus, interfering w/motility
- Associated with GERD→ Barret's
- Alcohol, smoking
- Progressive dysphagia, solid > liquid
- May need to vomit to relieve obstruction
- Sometimes pain, hematemesis, melena