Primary causes painless ulcer at site of entry (genital, peri-rectal or oral) ~3w following exposure - though can go unrecognized
Secondary weeks to months later w/rash on soles/palms, condyloma in genital/rectal area, peri-rectal pain or d/c, generalized adenopathy, F, sweats
Early latent: within 1y of acquiring, no symptoms or findings; + serological evidence dz
Late latent: > 1y after acquiring, no symptoms or findings; + serological evidence dz
Tertiary: years later, w/aortitis/aneurysms, granuloma development in skin, bones, other organs
Neurosyphilis: can occur at any stage; assoc w/CNS related numbness, weakness, balance problems, dementia, eye symptoms (red eye, pain, decreased vision)
Physical Exam Findings
Primary: painless genital, peri-rectal or oral ulcer, sometimes w/regional adnenopathy
Secondary: generalized non-puritic rash (can be macules and papules), w/predilection for palms, and soles, generalized adenopathy, Fever, sweats; condyloma lata--> frond-like growth in genital area