Granulomatosis With Poyangiitis (Wegeners)

Sites

  • Lungs
  • Kidneys
  • Skin
  • Eyes
  • Nasal mucosa/upper respiratory tract
  • Peripheral nerves

Etiology

  • Idiopathic vasculitis

Symptoms

  • Rash, eye sx
  • Recurrent/progressive nasal congestion and/or bleeding, cough, f, c, night sweats, wheezing, hemoptysis
  • Myalgias, arthralgias, fatigue
  • Peripheral nerve involvement--> extremity numbness, pain, and/or weakness
  • Lab evidence glomerulonepthritis
  • Often delays in dx as unusual→ rx for more common infxn/inflam processes

Physical Exam Findings

  • Arthritis
  • Nasal mucosal erythema or ulcer
  • Nasal septum perf
  • Papable purpura (vasculitis)
  • Red eye (scleritis, uveitis)
  • Peripheral neuropathy related: decreased distal sensation, weakness, diminished reflexes

Tests

Links