Granulomatosis With Poyangiitis (Wegeners) (GPA)

Your Path

  • Granulomatosis with poyangiitis (Wegeners) (GPA)


  • Kidneys
  • Skin
  • Eyes
  • Nasal mucosa/upper respiratory tract, lungs - w/25% GPA affecting respiratory tract only (limited GPA)
  • Peripheral nerves


  • Idiopathic vasculitis

Risk Factors

  • Men = women
  • Average age 40-60


  • Rash, eye sx
  • Recurrent/progressive nasal congestion and/or bleeding, cough, f, c, night sweats, wheezing, hemoptysis
  • Myalgias, arthralgias, fatigue
  • Peripheral nerve involvement--> extremity numbness, pain, and/or weakness
  • Lab evidence glomerulonepthritis
  • Often delays in dx as unusual→ rx for more common infxn/inflam processes

Physical Exam Findings

  • Arthritis
  • Nasal mucosal erythema or ulcer
  • Nasal septum perf
  • Focal lung findings; findings c/w ILD
  • Papable purpura (vasculitis)
  • Red eye (scleritis, uveitis)
  • Peripheral neuropathy related: decreased distal sensation, weakness, diminished reflexes