- Genetic disorder affecting multiple organs due to production of thickened, ineffective mucous
- Can present from infant to young adult, based on degree of dysfxn
- Sinuses→ obstructive sx, recurrent infection
- Lung→ recurrent infections, w/progressive sob, doe, wheezing, progressive lung destruction
- Pancreatic insufficiency→ wt loss, small stature, and diarrhea
- Absent vas deferens (men)→ infertility
- Impaired cervical mucous→ infertility (women)
- Tendency to dehydrate easily w/activity
- Short/low weight
- Absent vas deferens in males