- Nasal mucosa/upper airways
- Peripheral nerves
- Vasculitis w/high levels circulating and tissue invasive eosinophils
- Muscle aches
- Heart failure
- Adult onset asthma, cough & wheezing
- Nasal stuffiness→ w/resp sx usually ~2-10 y prior to systemic sx assoc w/eosinophilic deposition in target organs and vasculitis
- In these later phases→ systemic sx including: sob from parenchymal lung involvement; less commonly causes ILD
- Hematuria from renal involvement
- Pericarditis and dysrhythmia w/cardiac involvement
- Peripheral neuropathy related numbness, weakness
- Skin findings of vasculitis: small, palapable purpura, dont blanch when compress them, can coalesce
- Hematuria/renal involvement
- Unexplained peripheral neuropathy related decreased distal sensation, weakness, diminished reflexes
- Sometimes lung findings of ILD
- UA + RBCs, protein; Urine microscopy w/rbc casts, dysmorphic RBCs
- Serum: decrease in GFR; +eosinophilia; often + c-anca or p-anca
- PFTs