Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

Your Path

  • Eosinophilic granulomatosis with Polyangiitis (Churg-Strauss)


  • Lungs
  • Kidneys
  • Heart
  • Skin
  • Nasal mucosa/upper airways
  • Peripheral nerves


  • Vasculitis w/high levels circulating and tissue invasive eosinophils

Risk Factors

  • Men=women


  • Progressive
  • F
  • C
  • Muscle aches
  • Heart failure
  • Adult onset asthma, cough & wheezing
  • Nasal stuffiness→ w/resp sx usually ~2-10 y prior to systemic sx assoc w/eosinophilic deposition in target organs and vasculitis
  • In these later phases→ systemic sx including: sob from parenchymal lung involvement; less commonly causes ILD
  • Hematuria from renal involvement
  • Pericarditis and dysrhythmia w/cardiac involvement
  • Peripheral neuropathy related numbness, weakness

Physical Exam Findings

  • Wheezing
  • Skin findings of vasculitis: small, palapable purpura, dont blanch when compress them, can coalesce
  • Hematuria/renal involvement
  • Unexplained peripheral neuropathy related decreased distal sensation, weakness, diminished reflexes
  • Sometimes lung findings of ILD