Biochemical predispositions, consider in particular when unexplained DVT: protein S or C deficiency, Anti-thrombin 3 defic, Prothrombin mutation, factor 5 leiden resistance, anti-phospholipid AB (arterial and venous)
Acquired predispositions, often linked to clots in unusual places: nephrotic syndrome (renal vein), p vera (hepatic vein), HIT, ET (arterial and venous), PNH, hyperhomocystinemia
Mechanical predispositions that compress veins→ stasis→ clot
Can have contribution from more than one RF
Symptoms
Cough
SOB
Hemoptysis
Acute or subacute if recurrent events
Chest pain (often pleuritic)
Lightheaded, dizzy, syncope/presyncope (based on degree of compromise)