- 80% staph, strep
- Other less common organisms HACEK, Coxiella, T Whiplei, fungal
- Prior endocarditis
- Unrepaired cyanotic congenital heart dz
- Prosthetic valve
- Acquired R sided valvular heart dz (in particular, tricuspid)
- Systemic embolic events w/seeding and assoc sx
- Sob w/septic emboli to lung w/infxn right sided valves
- Rapidity of clinical progression affected by organism and pt substrate
- New or worse murmur
- Relatively rare skin findings include Janeway lesions→flat, painless, erythematous lesions on hands
- Osler's nodes→ painful nodules on fingers, findings associated w/seeding→ e.g. lbp or neuro findings from vertebral osteo, epidural abscess
- Focal neuro deficits from stroke or brain abscess
- Lung findings of infiltrate