Hereditary Angioedema

Etiology

  • Rare
  • Related to C1 inhibitor deficiency

Risk Factors

  • Sometimes family hx similar events
  • Requires rx directed at compliment cascade & its products

Symptoms

  • Onset early age
  • Sob
  • Swelling
  • Abd pain
  • No itching
  • Often no trigger
  • Can start in one area of body and spread
  • Sx last several days
  • Resolves in hours to days
  • Can be life threatening due to airway issues

Physical Exam Findings

  • Tongue
  • Stridor
  • Resp distress
  • No urticaria
  • Swelling of face
  • Non-pitting edema of face/hands/legs/genitalia/other body parts