- Idiopathic, genetic or mixed causes
- Can present from kids to adults
- Can have symmetric, focal or obstructive hypertrophy
- Affected areas of the ventricle are thickened; at microscopic level, myocytes are not correctly arrayed
- Initially asx, then can develop DOE, SOB, fatigue, and other symptoms of heart failure
- Chest pain, palpitations
- A fib often develops, which can exacerbate sx
- Presyncope/syncope or sudden death can occur from spontaneous VT
- Non-obstructive hypertrophy may have no findings unless/until heart failure develops
- With dz obstructing outflow track--> crescendo decrescendo systolic murmur, loudest along L sternal border; Intensity increases w/decreased preload--> valsalva, standing; Intensity decreases w/increased preload--> squatting