- Primary FSGS→ most common cause idiopathic nephrotic syndrome→ 30-50% of cases, particularly common in black adults
- Secondary FSGS→ Hiv, obesity, heroin, other
- Primary or secondary can progress to ESRD
- Other symptoms can be related to primary process
- Unexplained venous thrombosis
- Nephrotic range proteinuria: > 3.5g protein in a 24h urine collection
- Spot urine protein/creat ratio: Normal < 150mg/g; 3500mg/g roughly =s 3.5g protein/24h collection
- Spot urine albumin/creat ratio: Normal < 30mg/g; moderately increased albuminuria 30-300mg/g; severely increased albuminuria > 300mg/g; 3500mg/g roughly =s 3.5g albumin/24h collection
- Low serum albumin, hyperlipidemia
- GFR typically decreased