Membranous Nephropathy

Etiology

  • Age > 50
  • Accounts for ~30% of nephrotic syndrome in adults
  • 75% of cases are primary, with most of those anti-PLA2R antibody +
  • 25% of cases are secondary, associated w/Hepatitis B or C, SLE, meds (e.g. NSAIDs, gold, penicillamine, other), syphilis, malignancy (e.g. lung, colon, other)

Symptoms

  • Develops over months
  • Symptoms related to volume overload
  • GFR may be preserved
  • Unexplained venous thrombosis

Physical Exam Findings

  • Peripheral edema
  • Sometimes periorbital and hand edema
  • BP can be normal

Tests

Links