- Acounts for 70-90% of Nephrotic syndrome in kids
- 10-15% in adults
- Idiopathic though assoc w/meds (lithium, nsaids), infxn (mono)
- Malignancies (lymphoma)
- Edema develops rapidly (over weeks)
- GFR often preserved
- Unexplained venous thrombosis
- Peripheral edema
- Sometimes periorbital and hand edema
- HTN may be present
- Nephrotic range proteinuria: > 3.5g protein in a 24h urine collection
- Spot urine protein/creat ratio: Normal < 150mg/g; 3500mg/g roughly =s 3.5g protein/24h collection
- Spot urine albumin/creat ratio: Normal < 30mg/g; moderately increased albuminuria 30-300mg/g; severely increased albuminuria > 300mg/g; 3500mg/g roughly =s 3.5g albumin/24h collection
- GFR often preserved
- Low serum albumin, hyperlipidemia