POEMS

Poly-neurop, organomeg, endocrinop, mono-clonal gammop, skin changes

Etiology

  • Idiopathic

Symptoms

  • Distal numbness
  • Fatigue
  • Skin probs
  • Volume overload
  • Progressive over mos
  • Weakness distal>proximal
  • Major features are neuro & mono-clonal gammop
  • Others not always present

Physical Exam Findings

  • Splenmegaly
  • Hepatomegaly
  • Edema
  • Adenopathy
  • Skin changes
  • Not all present
  • Decreased distal sensation
  • Diminished reflexes