Biochemical predispositions, consider in particular when unexplained DVT: protein S or C defiicency, Anti-thrombin 3 defic, Prothrombin mutation, factor 5 leiden resistance, anti-phospholipid AB (arterial and venous)
Acquired predispositions, often linked to clots in unusual places: nephrotic syndorme (renal vein), p vera (hepatic vein), HIT, ET (arterial and venous), PNH, hyperhomocystinemia
Mechanical predispositions that compress veins→ stasis→ clot
Can have contribution from more than one RF
Upper extremity DVT in particular associated w/central venous catheters and/or cancer
Symptoms
Acute swelling of calf/ankle
Asymmetric edema
Localized discomfort
No other explanation for symptoms
CP or SOB if also PE
Physical Exam Findings
Unilateral edema otherwise unexplained of leg, calf/ankle (or arm if UE DVT)