Your Path

  • DVT

Risk Factors

  • Smoking
  • Immobility, w/risk increasing based on degree: long car ride, plane ride, bed bound
  • Active cancer → in particular mucin secreting adenocarcinomas, NHL, AML, others
  • Meds→ e.g. estrogen
  • Trauma/vascular injury, surgery
  • Chronic intravascular catheters
  • Pregnancy - w/hypercoag state extending ~6w post-partum
  • Chronic inflammatory conditions→ IBD, lupus, Behcet's dz, etc
  • Prior hx DVT or PE
  • Biochemical predispositions, consider in particular when unexplained DVT: protein S or C defiicency, Anti-thrombin 3 defic, Prothrombin mutation, factor 5 leiden resistance, anti-phospholipid AB (arterial and venous)
  • Acquired predispositions, often linked to clots in unusual places: nephrotic syndorme (renal vein), p vera (hepatic vein), HIT, ET (arterial and venous), PNH, hyperhomocystinemia
  • Mechanical predispositions that compress veins→ stasis→ clot
  • Can have contribution from more than one RF
  • Upper extremity DVT in particular associated w/central venous catheters and/or cancer


  • Acute swelling of calf/ankle
  • Asymmetric edema
  • Localized discomfort
  • No other explanation for symptoms
  • CP or SOB if also PE

Physical Exam Findings

  • Unilateral edema otherwise unexplained of leg, calf/ankle (or arm if UE DVT)
  • Sometimes redness
  • Sometimes dilated superficial veins