- Systemic response to a precipitant, including: meds, food, latex, insect bite/stings, other environmental triggers
- IgE mediated mast cell degranulation
- Acute onset, within minutes to few hours of exposure
- Respiratory: SOB, DOE
- Cardiovascular: syncope/presyncope
- GI: nausea, vomiting, abd pain
- Muco-Cutaneous (present in up to 90% of cases): itching, redness, angioedema (swelling of skin, mucosa)
- Can be life threatening
- Low blood pressure, elevated heart rate
- Hives, edema and redness of face, extremities, chest/back
- Lips, muoscal (e.g. uvula, tongue) swelling