Other: steroids, OCPs, acetaminophen (the most common cause of DILI in US), Ace-I, anti-fungals, anti-retrovirals, PTU, toxins (e.g. amanita mushrooms), and more
May have chronic/underlying liver disease (e.g. NAFLD, Hep C, ETOH) with additional med/toxin effect superimposed
Symptoms
Range from non-specific to fulminant liver failure
Jaundice, edema, mild confusion to coma - depending on degree of end organ dysfunction
Physical Exam Findings
Appearance ranges from no acute distress to very ill
Tests
Predominantly hepatocellular pattern of injury; can have cholestasis , as well as mixed patterns
Labs to r/o other contributors: viral hepatitis, auto-immune hepatitis, other smoldering/underlying process (e.g. Wilsons, Hemochromatosis), acetaminophen levels (as there's an antidote)
Imaging to assess for structural disease, obstruction