- Antibiotic associated colitis
- Most commonly implicated antibiotics: clindamycin, cephalosporins, quinalones; though can occur after any abx
- Also passed to patients in hospital via healthcare workers
- Prior history of c dif
- Advanced age; significant medical conditions including: cancer, renal failure, generalized debility; chemotherapy
- Diarrhea, at least 3x/day
- Sometimes nausea, vomiting
- Sometimes blood in stool
- Severe pain and sepsis if advanced
- May have generalized abd pain
- Sometimes distention
- With severe disease--> toxic megacolon--> very ill
- PCR testing of stool (very sensitive, less specific)
- Stool toxin assay (specific, less sensitive)
- Endoscopic appearance
- May have very elevated serum WBCs