Liver Cancer (Hepatocellular)


  • Chronic hepatitis for any reason (typically x many years), leading to cirrhosis
  • Can also be mets to liver

Risk Factors

  • Chronic alcoholic hepatitis
  • Chronic hepatitis B, C
  • Fatty liver-->NASH
  • Hemochromatosis, Wilson's disease, other uncommon genetic disorders
  • Sometimes from multiple contributors (e.g. ETOH + Hep C)


  • Anorexia
  • Weight loss
  • Fever, sweats
  • RUQ/epigastric persistent/progressive discomfort

Physical Exam Findings

  • Palpable
  • Firm liver if advanced