- Most common cause of hyperthyroidism 50-80% of cases
- Irritability
- Diarrhea
- Palpitations
- Tremor
- Weight loss
- Weakness
- Infertility
- ED
- Heat intolerance
- Menstrual irregularity
- Typically progressive over 2-3m
- Diffusely enlarged thyroid, sometimes bruit
- Exopthalmous or ophthalmopathy in up to 25%
- Elevated T4, suppressed TSH
- Elevated anti-thyroptropin receptor antibodies 99% sensitive and specific for Graves
- Thyroid w/diffuse increase in uptake by radionuclide scan