- Clostridium Tetani (GPR)
- Exposure via contaminated wounds
- Toxin taken up by pre-synaptic side of NMJ--> travels to spinal cord--> blocks release of inhibitory neurotransmitters--> spasticity
- Vaccination markedly decreases incidence dz w/50 cases/y US
- Lack of vaccination
- Dirty, contaminated wound, often w/devitalized tissue
- Injection drug use with contaminated needle/product, through dirty skin
- Increased tone in jaw muscles
- Diffuse musle pain/spasms
- Airway compromise