- Travel to endemic areas of tropical/sub-tropical South America, Sub-Saharan Africa
- Non-use of mosquito protection
- Incubation 3-6d
- Fever
- Confusion
- N
- 80% of those infected have sx
- Spectrum of illness w/15% severe
- Jaundice/icterus w/hepatic involvement
- Spontaneous bleeding from coagulopathy
- Decreased urine output from AKI
- Multi-system organ failure